“HUMAN TLR8 – SELECTIVE AGONISTS”

Co-Inventors: Sunil A. David, Mallesh Beesu, Giuseppe Caruso, Alex Salyer.

The patent describes the identification of new molecules with adjuvant activity for the development of new vaccines characterized by a good tolerability profile. In particular, the candidate molecules are part of the family of Toll-Like Receptors 8 agonists, capable of stimulating the innate immune response.

Application number: 15/754193

International Classes: C07D215/38; A61P37/02

United States Patent Application: 20180258045 A1

Submission date: August 19, 2016

Publication Date: September 13, 2018

“AMPHOTERICIN B AS AN ADJUVANT”

Co-Inventors: Sunil A. David, Subbalakshmi S. Malladi, Karishma Khetani, Giuseppe Caruso, Lauren Fox, Alex Salyer.

The patent is based on the results obtained through the screening of more than one hundred thousand molecules which demonstrated the therapeutic potential of amphotericin B as an effective and safe adjuvant for vaccines. This antifungal drug has demonstrated a significant adjuvant activity at low doses, with a good tolerability and safety profile.

Application number: 62/287663

Submission date: January 27, 2016